Deciphering Alzheimer disease.

Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.

Defining molecular targets to prevent Alzheimer disease.

A n explosion of new techniques to explore DNA and protein biology during the last 2 decades has illuminated one of the most enigmatic and intractable subjects in biomedicine—neurodegeneration. Eponymic diseases of the nervous system that were until recently characterized by mechanistic ignorance and therapeutic nihilism are falling steadily to the power of molecular genetics, cell biology, bio...

NEUROLOGICAL REVIEW Defining Molecular Targets to Prevent Alzheimer Disease

A n explosion of new techniques to explore DNA and protein biology during the last 2 decades has illuminated one of the most enigmatic and intractable subjects in biomedicine—neurodegeneration. Eponymic diseases of the nervous system that were until recently characterized by mechanistic ignorance and therapeutic nihilism are falling steadily to the power of molecular genetics, cell biology, bio...

P 59: Non-Steroidal Anti-Inflammatory Drugs as a Prevention of Alzheimer Disease: Risks and Benefits

Alzheimer's disease (AD) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. The exact cause of Alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. This brings in mind using non-steroidal anti-inflammatory drugs (NSAID) as treatment or prevention of the disease. ...

New Insights into the Effect of Diabetes and Obesity in Alzheimer’s Disease

Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in...